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Davies-Jenkins, View ORCID ProfileHelge J
The Impact of Obesity on GLP-1 Levels Obesity is a significant risk factor for developing insulin resistance and type 2 diabetes
Emphasis is placed on mechanistic properties, signaling hypotheses, and system-level interaction
Therefore, drugs with a potent antihyperglycemic effect, independent of the glomerular filtration rate, with a low risk of hypoglycemia, that reduce weight in overweight/obese patients and that provide cardiovascular and renal protection, such as GLP-1 receptor agonists, are needed
161 Further, cytosolic GOT1 inhibition decreases oxaloacetate levels and reduces the cellular NADPH/NADP + and GSH/GSSG ratios
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