6 Systemic manifestations Systemic manifestations are common and include flulike symptoms, fever, lymphadenopathy, and mucosal involvement (conjunctival, oropharyngeal, esophageal, and genital)
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(3) removing Fmoc protecting groups, and sequentially coupling by coupling Fmoc or Boc protected alpha amino acid or peptide segments according to the sequence of semaglutide and then removing the Fmoc protecting groups, wherein the coupling sequence of the Fmoc or Boc protected alpha amino acid is as follows: Fmoc-Arg (Pbf) -OH, Fmoc-Gly-OH, Fmoc-Arg (Pbf) -OH, Fmoc-Val-OH, Fmoc-Leu-OH, Fmoc-Trp (Boc) -OH, Fmoc-Ala-OH, Fmoc-Ile-OH, Fmoc-Phe-OH, Fmoc-Glu (OtBu) -OH, Fmoc-Lys (Alloc) -OH, Fmoc-Ala-OH, Fmoc-Gln (Trt) -OH, Fmoc-Gly-OH, Fmoc-Glu (OtBu) -OH, Fmoc-Leu-OH, Fmoc-Tyr (tBu) -OH, Fmoc-Ser (tBu) -OH (Fmoc-Ser (tBu) -OH, Fmoc-Val-OH, Fmoc-OtBu (Asp), (Asp, Fmoc-Val) -OH, Fmoc-Leu-OH, Fmoc-Leu-Asp (Ser-Leu) -OH, Fmoc-Leu-OH, Fmoc-Ser (Ser-Leu) -OH, Fmoc-Gly-Leu-OH, Fmoc-Gly-OH, Fmoc-Ser (Ser-OH, Fmoc-Gly-OH, Fmoc-Gly-Ser-Leu-OH, Fmoc-Ser-OH, Fmoc-Ser-OH, etc, Fmoc-Thr (tBu) -OH, Fmoc-Phe-OH, Fmoc-Thr (tBu) -OH, Fmoc-Gly-OH, Fmoc-Glu (OtBu) -OH, Fmoc-Aib-OH, Boc-His (Trt) -OH

Carter BZ, Mak DH, Schober WD, Cabreira-Hansen M, Beran M, McQueen T, Chen W, Andreeff M
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