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doi: 10.26508/lsa.202000786 16
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These modifications reduce its affinity for insulin-like growth factor binding proteins, particularly IGFBP-3, which normally sequesters a large majority of circulating native IGF-1
This study revealed a complex metabolic situation determined by insulin and palmitate in CACT-deficient cells, and has provided insight into the functional interactions between CACT, CPT1, malonyl-CoA, and acetyl-carnitine 59
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