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Bariatric patients have had surgical intervention, while GLP-1 patients are managing obesity through medication but both are treating the same chronic disease

The main safety concern involves compounded GLP-1 medications, which lack FDA oversight for quality and consistency

while the addition of an SGLT-2i to GLP-1RA treatment showed only an increased incidence of genital infection (RR: 2.54

Hepatokines (e.g., FGF21) and extracellular vesicles influence cardiac tissue, vascular tone, and systemic metabolism, potentially amplifying inflammation, oxidative stress, and lipotoxicity across organs

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