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Figure 3 Moreover, increased systematic translocation of intestinal metabolites, bacterial particulates, or even microbiota through the damaged intestinal tract (the leaky gut) heightens systemic inflammatory reactions such as Th17/Treg disorder, interleukin-6, IL-1, and tumor necrosis factors alpha that are being implicated in the etiology of depression

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Peroxisomal -oxidation is incomplete and is responsible for the oxidation of very long-chain fatty acids (VLCFAs) and branched-chain fatty acids (BCFAs) that are incompatible with mitochondrial enzymes to produce some shorter acyl-CoAs [28]