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Professor Emily Oster: A thing we unfortunately don't have is large, randomized trials with many years of follow-up where people are at a GLP-1 versus not and they've been breastfeeding
For a 30 mg retatrutide vial that will supply multiple weekly doses, BWFI is the standard choice
The pattern is that both are GI-forward drugs, but retatrutides glucagon activity adds a cardiovascular consideration (heart rate) that cagrilintides amylin mechanism does not, and the same potency that produces retatrutides larger weight loss is associated, in indirect analyses, with a heavier adverse-event load
[1] [22] Both formulations carry a boxed warning regarding thyroid C-cell tumors observed in rodent studies, though the clinical relevance to humans remains uncertain
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