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Regulation of energy metabolism through modulation of acyl CoA:CoA ratio Free (nonesterified) CoA is required as a cofactor for numerous cellular reactions

From a mechanistic perspective, GLP-1RAs like exenatide notably decreased the percentage of Th17 cells while promoting the proliferation of Tregs by influencing the signaling cascade encompassing phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), along with forkhead box O1 (FoxO1) [147]

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