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98 Although located in the sinoatrial node, GLP-1 RAs influence the cardiovascular system through several other mechanisms, including the use of myocardial glucose, improvement of left ventricular function, myocardial ischaemic protection, increased heart rate, vasodilation, anti-atherosclerotic effects, and blood pressure reduction
I expect a lot of their next earnings calls to focus on oral semaglutide patients transitioning to injectables, she said
Dose-dependent increases in heart rate were also observed, consistent with the glucagon receptor agonism component of the drug, and this warrants careful monitoring in individuals with pre-existing cardiac conditions
Across multiple SUSTAIN trials, patients treated with semaglutide 0.5 mg or 1.0 mg weekly demonstrated statistically significant reductions in total cholesterol and LDL-C compared to placebo and several active comparators
Many patients see minimal scale change until they reach 5 mg or higher
