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The HCV NS3/4A protease suppresses innate immune responses by cleaving the adaptor proteins MAVS and TRIF, thereby blocking RIG-I and TLR3 signaling and inhibiting IRF-3 activation and IFN- production, though its inhibition can restore these responses, while variations in its catalytic efficiency are linked to viral pathogenicity and depend on specific nonstructural protein 4 A (NS4A) cofactor residues for enhanced activity [248]

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After reaching a stable weight, some patients remain concerned about changes in skin firmness, cellulite, or specific contour areas

Data in panel a was analyzed by 2-way ANOVA with Bonferronis post-hoc test for comparison of individual time points