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Missing occasional doses is unlikely to significantly impact overall results
The exact mechanism how DPP4 inhibitors augment insulin secretion and increase -cell mass in vitro and in vivo is still not fully understood, since not all these effects could be explained by elevated GLP-1 level or improved glycemic control associated with less glucotoxicity
3 The approval allows for a higher dose of 7.2 mg for maintenance in weight loss patients
The OASIS 4 trial demonstrated 13.6% mean body weight loss at 64 weeks with oral semaglutide 25 mgcomparable to injectable formulations
Eating every 2-3 hours becomes especially important to prevent blood sugar fluctuations
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