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Alitretinoin, a vitamin A derivative, has shown efficacy in treating hyperkeratotic CHE, with studies reporting significant improvements in Physician Global Assessment (PGA) scores [92]
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Deficiency can show up as fatigue, weakness, numbness/tingling, balance problems, memory issues, and megaloblastic anemia
Precision and Future Medicine
in fact, it is the most common GST expressed outside the liver
These peripheral and central deficits can include severe gastrointestinal lesions, intracranial (superior sagittal sinus) hypertension, brain swelling and lesions, portal and caval hypertension, aortic hypotension, peripheral and central thrombosis, inferior caval vein and superior mesenteric vein congestion, azygos vein failure, electrocardiogram (ECG) disturbances, and heart, lung, liver, and kidney lesions (Vukojevic et al., 2018
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