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The actions of agouti-related peptide (AgRP) neurons and pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (ARC), the most renowned cell types of the hypothalamus governing homeostatic actions and inducing hunger, were previously understood to be mainly regulated by internal nutritional status or hormones such as leptin or ghrelin [45]
Although not yet completed, cardiovascular outcomes of tirzepatide will likely be similar to GLP-1 RAs based on the mechanism of the drug
SURMOUNT-1, 72-week study of adults with obesity using Zepbound (tirzepatide 15mg)
Rash is considered an uncommon side effect of tirzepatide
It works on appetite from several angles at once
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