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The data showing cagrilintide preferentially reduces fat mass while preserving lean mass is compelling for researchers who care about body composition, not just the scale number

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In clinical trials, doses are escalated gradually over several weeks to improve tolerability a process known as dose titration

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Then, in 2015, Lee and colleagues identified a previously overlooked open reading frame within the 12S ribosomal RNA gene of mtDNA and found that it encodes a functional peptide, MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) [1]