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Neurofibrillary tangles have been found in the amygdala, hippocampal structure, parahippocampal gyrus, and temporal cortex of patients with AD, whereas senile plaques have been shown to be distributed throughout the combined neocortex and striatum (41)

An early clinical trial in 13 patients with type 2 diabetes found that a single intravenous infusion of 1,000 mg of lipoic acid improved insulin-stimulated glucose disposal (i.e., insulin sensitivity) by 50% compared to a placebo infusion (57)

These medications, which are used primarily for T2D management, have shown beneficial effects on both cardiac and renal diseases

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Potential changes in microorganisms and metabolites associated with oral cancer: a preliminary study