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These injections, usually containing hydroxocobalamin or cyanocobalamin, are administered intramuscularly, thus bypassing the digestive system where the absorption problem occurs

A peptide is a chain of amino acids held together by peptide bonds, and those bonds are precisely what digestive enzymes (pepsin, trypsin) are built to cut, with the acidic stomach environment finishing the job so an oral peptide is largely destroyed before it can be absorbed, which is why injection is the default

That slowdown signals metabolic adaptation, and that is when a second agent with a different mechanism provides the most benefit

Experience rapid benefits without waiting for the digestion and absorption process

The absorption speed of B12 depends on whether someone takes sublingual tablets that dissolve under the tongue or requires B12 injections