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It was noteworthy that approximately half of the residues exhibiting a substantial decrease in intensity were hydrophobic amino acids (Figure
TCA, tricyclic antidepressants
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R Substrates glucuronidated by UGTs include: Acetaminophen (Tylenol) Bilirubin (heme degradation product) Estrogens (estradiol, estrone, estriol) Morphine and opioids NSAIDs (ibuprofen, naproxen) Thyroid hormones (T3, T4) There are four UGT families: UGT1A, UGT2A, UGT2B, and UGT3A
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