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Patients who are pregnant or breastfeeding, patients with active malignancy, patients with certain vascular conditions where angiogenesis is a concern, and patients on specific anticoagulants may not be candidates

The plot provided a visual representation of the relative differences observed between the modified method and the reference protocol, along with the mean relative bias (Barr et al

For example, pharmacokinetic modeling and dose escalation studies can help establish appropriate drug concentrations and administration schedules

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