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An exploratory mediation analysis of stroke outcomes in the REWIND CVOT, in which dulaglutide reduced systolic blood pressure (SBP) by a mean of 1.7 mmHg compared to placebo, found that the blood pressure reduction caused by dulaglutide accounts for around 14% of its effect on stroke risk [21]
10.1158/1055-9965.EPI-08-0042 40 SunB
Most GLP-1 protocols recommend 1.2 to 2.0 grams of protein per kilogram of body weight per day to protect lean muscle mass during active weight loss
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