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Prokinetic agents such as metoclopramide or domperidone, which accelerate gastric emptying, may counteract some of the therapeutic effects of semaglutide on satiety and weight loss

Left atrial volume and E/e ratio are crucial parameters in HFpEF and their improvement with GLP1-RA, together with the reduction of inflammation markers, may explain the expected benefits of this class of drugs in patients affected by HFpEF

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138 Therefore, the activation of ferroptosis seems to be an important goal in cancer therapy, and triggering NFS1 might be a suitable strategy