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Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy

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Tirzepatide for reduction of morbidity and mortality in adults with obesity: rationale and design of the SURMOUNT-MMO trial

Clinical trials have shown that pairing these two agents may result in greater weight loss than either compound alone

The serine synthesis pathway is mainly supplied by glucose-derived 3-phosphoglycerate, which is converted into 3-phosphohydroxypyruvate by the action of phosphoglycerate dehydrogenase, which also converts NADH into NAD +