Also, both mutant and WT SOD1 produce cytotoxic levels of H 2 O 2 via a cysteine redox regulation system (Bakavayev et al., G93A mice show significantly increased protein carbonyl levels in the spinal cord, including elevated carbonylation of mutant SOD1, which has been linked to motor neuron degeneration (Poon et al., 2005)
Botta D, Franklin CC, White CC, Krejsa CM, Dabrowski MJ, Pierce RH et al
Oxidative stress, which destroys cells and impairs bodily function, can be brought on by free radicals
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