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doi: 10.1016/j.jaci.2022.11.007 52 WangSWangSWangXXuYZhangXHanYet al
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The turnover of carbohydrates, proteins, and lipids, and the production/storage of energy are necessary for survival
Common reasons Dose too low - may need to increase to therapeutic levels (2.4mg or higher) Not enough time - meaningful results typically take 8-12 weeks at adequate doses Calorie-dense liquid calories bypassing satiety signals - watch smoothies, alcohol, sugary drinks Eating through fullness signals - pay attention to your body's cues Inconsistent dosing schedule - must be same day each week for optimal levels Unrealistic expectations - 1-2 lbs per week is healthy, sustainable weight loss Key Research [1]"Once-weekly cagrilintide for weight management in people with overweight and obesity" Lau DCW et al., 2021 Finding: Phase 2 trial showed cagrilintide at 4.5mg achieved 10.8% weight loss versus 3% with placebo over 26 weeks in 706 participants
Given the banal nature of this ingredient, supplementation is sensible & may contribute at best to the placebo effect
