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In previous studies, p53 TAD was shown to significantly influence the DNA selectivity of p53 DBD, with the acidic residues of TAD believed to contribute to this selectivity through interactions with the basic residues of DBD 54

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The enzyme-inhibitor complexes show that the binding of ligand into the electrophilic binding site does not lead to any conformational changes of the protein

Vitamin D signaling in the context of innate immunity: focus on human monocytes