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Glutathione is the first line of defense against oxidative injury and can scavenge reactive oxygen species
Effect of metformin on glucose metabolism in the splanchnic bed
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During catalysis, the electrons are transferred from NADPH to FAD, then to the buried amino-terminal active site, to the carboxy-terminal active site of the other TrxR subunit, and from there to the substrate at the protein's surface
Siddiqui et al., 2011
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