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Dermatologists, plastic surgeons, and everyday users are noticing a distinct look that often accompanies success on these medications, one thats gaunt, slack, prematurely aged, and, by now, recognisable enough to have earned the nickname Ozempic Face. Dendy Engelman, MD, is one of those dermatologists: The skin appears thinner, and theres an almost deflated look to the mid-face and jawline, paired with dryness and fine lines, she says

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Supply constraints have periodically affected availability, with the FDA reporting shortages of several GLP-1 formulations throughout 2022-2024