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And when combined with acetyl hexapeptide-8 as in Argirelox it can be used to extend the anti-wrinkle effects of Botox injections.32 Syn-Ake In a recent 2024 study examining in silico and in vitro tests, Syn-Ake displayed antioxidant capabilities, meaning it could help scavenge free radicals and prevent them from damaging or aging skin.33 Additionally, a 2024 review explained that the peptide may prevent the uptake of sodium ions in muscles, keeping them relaxed and reducing the risk of developing wrinkles

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Retatrutide (LY3437943) also is a potent agonist at the mouse GCGR, GIPR, and GLP-1R in receptor binding affinity and functional potency assays in vitro

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