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doi:10.1210/endo.142.12.8522 Heffernan MA, Thorburn AW, Fam B, et al
Benefits of Vitamin D Injections
Yes, timing and route matter substantially, and the reason is the half-life
The peptide's signaling cascade engages within 20 to 40 minutes of injection, despite a plasma half-life of only 15 minutes
Oral dosing is most effective for GI conditions and has demonstrated systemic effects in animal models, though bioavailability is lower than injection (Sikiric et al., 2018)
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