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If A1c reduction is insufficient after adequate time at a given dose, escalation to the next tier is appropriate
Knapen LM, van Dalem J, Keulemans YC, van Erp NP, Bazelier MT, De Bruin ML,
This drug affects a major neurochemical in the brain, and if you interfere with that long-term, were not sure what the effects of that are going to be, Dr
Rastegarpanah M, Malekzadeh R, Vahedi H et al (2015) A randomized, double blinded, placebo-controlled clinical trial of silymarin in ulcerative colitis
I recommend starting conservatively with 0.25 mg daily for the first week regardless of injury severity
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