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Metformin may indirectly or directly affect the phosphorylation and nuclear translocation of STAT3 through the AMPK-mTOR pathway, thereby reducing its transcriptional activity and inhibiting the malignant phenotype associated with glioma stem cells (84, 8789)
3d), however, this is in the context of the CT-AMY 2 R complex adopting a CT conformation, compared to the bypass conformation stabilised by Cagri
(12) Repeat steps (9)(10)(11) until the fifth filtrate is collected
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