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In one study of women going through the menopause transition, the proportion of lean mass declined by about 0.6% per year while fat mass increased

10.1002/glia.24531 32 BavaR.CastagnaF.MusellaV.LupiaC.PalmaE.BrittiD

Moreover, SHANK3 knock-out in mice demonstrated that SHANK3 is associated with total brain volume and hippocampal size [108]

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