The peptide works systemically even when injected locally
Ma MZ, Chen G, Wang P, Lu WH, Zhu CF, Song M, et al
Hybrid Glutathione
In a statement to Insider, Novo Nordisk, the company that makes Wegovy and Ozempic, said that Gila monsters and the discovery of exendin-4 "did not have anything to do with our decision to develop long-acting GLP-1 receptor agonists" for obesity, because "that was based on GLP-1 biology in humans." But the company also said that "the GLP-1-like effect of exendin-4" in Gila monsters was "an important contribution to the field," as it led to the development of the very first injectable drug of its kind
In summary, growing evidence underscores that gut microbiota dysbiosis plays a pivotal role in both the development and outcome of ischemic stroke through immune, barrier, and metabolic pathways, suggesting that restoring gut microbial balance could become an essential strategy for stroke prevention and recovery