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Hydroxocobalamin BNF Drug Monograph
Patient advocacy is importantif symptoms persist despite normal test results, request further investigation or specialist referral, as borderline B12 levels may still cause symptoms in some individuals
The impurities that matter analytically are the ones that are structurally close to the target and therefore elute close to it: des-amido and deamidated forms, oxidation products, sequence variants that arose from incomplete coupling during synthesis, and forms where the fatty-acid conjugation is absent or attached at the wrong position
Gowdappa HB, Mahesh M, Murthy KV, Narahari MG
Spending money on high-dose B12 pills for this purpose is unlikely to be beneficial and should not replace evidence-based weight management approaches
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