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Neuroscience 89 : 637641

In ATTAIN-MAINTAIN, participants were randomized to a 12 mg dose of once-daily, oral orforglipron (or matching placebo) which was increased every 4 weeks until the randomized maintenance dose of 36 mg or MTD (24 mg or 36 mg) was reached

In conclusion, both SGLT2-i and GLP1-RA seem to have several effects on RAAS, though additional studies are needed to clarify this relationship

Plant-Based CICA PDRN (1%) derived from Centella Asiatica soothes sensitive skin while the vegan microbiome formula with kimchi-derived probiotics strengthens the skin barrier