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However, Heinz bodies are a very transient finding because they tend to be promptly pinched off by the spleen (thus giving rise to bite cells), and the red blood cells that contain them are very rapidly removed from the circulation
pregnancy, lactation, thyrotoxicosis, malignancy and liver or kidney diseases
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Long-term follow-up studies are needed to assess durability of therapeutic effects and to identify any delayed adverse effects or complications that might not be apparent in shorter-term investigations
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