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When empirical measures of parameter uncertainty (e.g., standard errors or confidence intervals) were not available from published sources, a conservative range of 25% was applied around the base-case value

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GLP-1 receptor agonists like semaglutide and tirzepatide work through an entirely different mechanism: they activate incretin receptors in the pancreas and brain to reduce appetite, slow gastric emptying, and improve insulin sensitivity

Over 72 weeks, average body weight reductions were 16.0% at 5mg, 21.4% at 10mg, and 22.5% at 15mg

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