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Such reactions will subtract RNS from critical cellular targets, such as cell membrane lipids and proteins belonging to the complexes of the electron transport chain, thereby explaining why GSH status appears to be so critical in modulating the susceptibility to NO
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Bioavailability is key: Liposomal delivery protects the molecule from digestion
Glutathione depletion can lead to increased oxidative stress, DNA damage, and impaired detoxification
