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Herniated discs affect roughly 2% of the general population at any given time, with the L4-L5 and L5-S1 levels accounting for approximately 95% of lumbar herniations

As anticipated, EVs derived from VDAC1-deficient cells exhibited markedly reduced VDAC1 and P-gp levels compared to control EVs ( Figure 3C ), suggesting a critical association between EV-derived VDAC1 protein and chemoresistance acquisition

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