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No pattern of serious adverse events has been observed in the human studies completed to date
Suggested Use: Take one lozenge by mouth as needed, with or without food
Smaller fragments are currently being studied as a substitute for whole antibodies in an effort to improve access and uptake
Carry a small source or sugar (such as glucose tablets or sugar) to consume if you symptoms of low blood-sugar appear
After entering the cochlea, cisplatin is taken up into cells by diffusive and passive transport, copper transporter protein 1 (Ctr1) and organic cation transporter protein 2 (OCT2), endocytosis, and toxicity through DNA adduct formation, oxidative stress, mitochondrial dysfunction, inflammatory response, and ferroptosis ( 2.1 Cisplatin-induced DNA damage and apoptosis Once cisplatin enters the cell it can be hydrolyzed to form toxic aqua-cisplatin complexes and form intra-and interstrand crosslinks with DNA (Mukherjea et al., 2011)
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