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17,22 Moreover, dietary antioxidants such as curcumin and resveratrol face obstacles in clinical development because of their inconsistent efficacy and unclear mechanisms of action
Upregulated humoral factors, such as Midkine, further promote tubulointerstitial injury by accelerating local NETosis and subsequent tubular cell death (220)
Proc Natl Acad Sci U S A 102:11722, PMID: 15618409 Qanungo S, Starke DW, Pai HV, Mieyal JJ, Nieminen AL (2007) Glutathione supplementation potentiates hypoxic apoptosis by S -glutathionylation of p65-NFkappaB
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Lancet 395, 10331034
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