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After screening titles and abstracts, 64 studies were selected for full-text review, and 41 articles were ultimately included in this review, including 12 randomized controlled trials, 16 observational studies, and 13 mechanistic or preclinical studies
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For instance, models with active malignancies (such as pituitary adenomas or breast cancer) face risks from increased growth hormone (GH) stimulation, which could exacerbate disease progression
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