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And with weight gain comes the return of insulin resistance. If you discontinue the medication, lifestyle interventions can partially preserve insulin sensitivity improvements after you stop taking the meds, says Silvana Obici, MD, the chief of the division of endocrinology at Stony Brook Medicine and the medical director of the Stony Brook University Hospital Diabetes Center in New York

Your body does not distinguish between fat and muscle when it needs energy, so without deliberate protein intake, you can lose both

Naltrexone/bupropion: an investigational combination for weight loss and maintenance

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Professional guidelines from organizations such as the American Gastroenterological Association and the Endocrine Society recommend that weight management treatment, including pharmacotherapy, be provided within the context of ongoing clinical care with regular monitoring