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A major driver for this expenditure is wishing to prevent and/or treat metabolic diseases (189) Based on the survey The Italian food supplement supply chain, 2019-2020 by the FederSalus Research Centre (that is the national agency of the Italian producers and distributors of food supplements), in late 2019, the food supplement market in Italy reached a value of approximately euro 3.6 billion (190), corresponding to 27% of the euro 13.2 billion value of the European market, thus preceding Germany and France (18 and 8%, respectively)

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Causes of deficiency can include an insufficient diet of animal products, gastrointestinal problems that affect absorption, and certain autoimmune medical conditions