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To further compare GSH synthetic capacities of different pathways, GSH1 gene of engineered strain W303-1b/F was deleted to eliminate synthesis of GSH by endogenous enzymes
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Alternatively, perhaps sites of ER-mitochondrial contact facilitate spatially restricted exchange of glutathione as they do for other metabolites such as calcium and reactive oxygen species (Joseph, Booth, Young, & Hajnoczky, 2019)
Risks include weight gain, diabetes, bone loss, and immune suppression
preclinical evidence only
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