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"Increased ectopic fat such as liver fat or visceral adipose tissue is commonly seen in adults with type 2 diabetes and is associated with an inflammatory response and increased cardiometabolic risk," said Amalia Gastaldelli, Ph.D., Research Director of Cardiometabolic Risk Unit, Tirzepatide is a novel investigational once-weekly dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that integrates the actions of both incretins into a single molecule, representing a new class of medicines being studied for the treatment of type 2 diabetes
The major issue that were running into is that these medications are cost prohibitive to the patients that are most likely to glean benefit, Stanford said
Long-term Safety Considerations: While the medications have been highly effective in managing diabetes and weight, there have been concerns about the potential long-term risks of GLP-1 receptor agonists, such as pancreatitis Factors That Increase Pancreatitis Risk With GLP-1 Initiation, stomach paralysis Ozempic Stomach Paralysis and thyroid cancer
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