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This makes it particularly relevant in clinical contexts where someone has gut lining compromise alongside systemic inflammation, for example, long-term NSAID use for chronic pain

Multi-dose safe with proper technique

All quantitative safety findings derive from animal and in-vitro models

Another large study showed that using GLP-1s may help prevent immune-related diseases in people with diabetes or obesity People with diabetes who took GLP-1 drugs had a lower chance of developing rheumatoid arthritis, gout, and osteoarthritis compared to people on other diabetes medications

Thats why its listed as the active ingredient in some overthecounter heartburn medications