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Outcomes The primary outcome was the percentage of body weight loss associated with naltrexone-bupropion over 12 months, in comparison with body weight loss in the control group

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Treatment typically begins with a low starter dose (0.25 mg weekly for 4 weeks), followed by gradual increases (0.5 mg, then up to 12 mg weekly for Ozempic, or up to 2.4 mg for Wegovy), depending on tolerability and clinical response

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Accordingly, administration of exendin (939) reversed the sitagliptin-induced improvement in ventricular function in Sprague Dawley rats with transient cardiac ischemia (190)