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Preliminary results from a late-stage trial involving adults with obesity and knee osteoarthritis showed average weight loss of about 28.7% after 68 weeks, suggesting the drug may be even more effective than earlier treatments

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In individuals with diabetes and fatty liver diseases, glucagons hepatic actions may be partly impaired resulting in elevated levels of glucagonotropic amino acids, dyslipidaemia and hyperglucagonaemia, reflecting a new, so far largely unexplored pathophysiological phenomenon termed glucagon resistance