To explore this idea, we bred the MMTV-PyMT transgenic mouse strain (which spontaneously develops breast tumours) 26 with an uninduced Gclc f/f Rosa26 creERT2 mouse 27 in which the rate-limiting step in GSH synthesis, the glutamatecysteine ligase catalytic subunit (GCLC), can be knocked out throughout the body after induction with tamoxifen
Secondary and exploratory outcomes included changes in waist circumference, body composition, and glycated hemoglobin (HbA1c), a validated marker of long-term glycemic control
Speaker Andrew Peseski, DO (Assistant Professor of Medicine, Division of Hematology, Duke University Medical Center) This weekly conference is held each Tuesday from 8-9 a.m
Handle with proper laboratory safety precautions.
A recent study found that certain GIPR genetic variants that impair both Gs and beta-arrestin 2 recruitment are linked to lower adiposity 38 , suggesting that GIPR effects on body weight involve complex signalling pathways