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Blood pressure actually improved in most participants, a benefit attributed to weight loss and improved insulin sensitivity outweighing any direct cardiovascular stimulation from the drug itself
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Some patients report that these opposing effects partially cancel each other out, with phentermine providing energy during the day while tirzepatide reduces caloric intake throughout the full 24-hour cycle
McGuire, MD, MHSc , professor of medicine in the division of cardiology, Dallas Heart Ball Chair for Research on Heart Disease in Women and Distinguished Teaching Professor at the University of Texas Southwestern Medical Center, presented results of SOUL at the American College of Cardiology Scientific Session in March, with simultaneous publication in The New England Journal of Medicine
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