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Both the LEADER (liraglutide) and SUSTAIN-6 (subcutaneous semaglutide) trials reported significant reductions in the primary outcome (incidence of MACE)
Head-to-head trials should compare long-term benefits of different combination regimens
One of its most notable traits is the peptides ability to augment the nitric oxide system that is key to blood flow and vascular health
Figure 1 Stacked donut charts depicting reasons for GLP-1RA therapy discontinuation stratified by lines of therapy (A), and contribution of specific agent to the 3 categories of discontinuation reasons (B) GLP-1, glucagon-like peptide 1 With respect to specific agents, the treatment-related reasons for discontinuation were reported most frequently with liraglutide (50%), followed by dulaglutide (32%), and semaglutide (18%)
The health coaches guide patients through lifestyle changes while medical providers can prescribe medications like semaglutide if appropriate
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